Low Dose Naltrexone

LDN

What is Low Dose Naltrexone?

Low dose naltrexone (LDN) is a medication that is used to treat a variety of conditions, including chronic pain, autoimmune diseases, and depression. It is a low-dose version of the drug naltrexone, which is used to treat opioid addiction.

LDN works by blocking the opioid receptors in the brain. This causes a release of endorphins, which are the body's natural pain relievers. LDN also has anti-inflammatory effects.

What are the Uses of LDN?

LDN has been shown to be effective in the treatment of a variety of conditions, including:

  • Chronic pain

  • Autoimmune diseases such as Hashimoto’s thyroiditis, rheumatoid arthritis, lupus, and multiple sclerosis

  • HIV/AIDS

  • Fibromyalgia

  • Crohn's disease

  • Inflammatory bowel disease

  • Sjögren's syndrome

  • Sleep disorders

  • Depression and Anxiety

LDN Risks

LDN is not FDA approved for uses outside opiate withdrawal and weight loss when combined with Bupropion in a medication called Contrave. LDN is generally considered to be safe, but there are some potential risks, including:

  • Headaches

  • Nausea

  • Dizziness

  • Fatigue

  • Sleep disturbances

  • Vivid dreams

  • Mood swings

Is LDN Right For Me?

The research on the effectiveness of LDN is still ongoing, but there is some evidence that it can be effective in treating a variety of conditions. Patients report improved energy, decreased inflammation, improvement in joint pain, and improvement in quality of sleep. A 2018 review of studies found that LDN was effective in reducing pain in people with chronic pain.

LDN is a promising treatment for a variety of conditions, but more research is needed to confirm its effectiveness and safety. If you are considering taking LDN, we are equipped at Evergreen to assist you.

Here are some additional resources that you may find helpful:

  • LDN Research Trust: https://ldnresearchtrust.org/

  • Low Dose Naltrexone: A Review of the Literature: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313374/

  • Low Dose Naltrexone for Chronic Pain: A Systematic Review and Meta-Analysis: https://pubmed.ncbi.nlm.nih.gov/32845365/